Cryptic crossword clue
I’m uplifted in middle of saintly sermon 6

The most common and most likely answer to this crossword clue is the 6 letter word HOMILY

I've seen this crossword clue in The Sunday Telegraph
H
O
M
I
L
Y

Buddy explains!

The straight part
We know that "sermon" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sermon = homily.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HOMILY mean?

HOMILY noun
  1. A sermon, especially concerning a practical matter.
  2. A moralizing lecture.
  3. A platitude.

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