Cryptic crossword clue
Immigrant lives west of Southwark area 5

The most common and most likely answer to this crossword clue is the 5 letter word ISSEI

I've seen this crossword clue in The Times
I
S
S
E
I

Buddy explains!

The straight part
We know that "Immigrant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case immigrant = issei.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ISSEI mean?

ISSEI noun
  1. A member of the first generation of Japanese immigrants to North America, South America or Australia.

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