Cryptic crossword clue
Impious bishop on island about to engage in affair 10

The most common and most likely answer to this crossword clue is the 10 letter word IRREVERENT

I've seen this crossword clue in The Times
I
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Buddy explains!

The straight part
We know that "Impious" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case impious = irreverent.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IRREVERENT mean?

IRREVERENT adjective
  1. Lacking respect; not having or not showing respect for or seriousness towards something that is usually treated with respect; going against conventional precepts.

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