Cryptic crossword clue
Imply a lot must change in best manner 9

The most common and most likely answer to this crossword clue is the 9 letter word OPTIMALLY

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "n best manner" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case n best manner = optimally.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OPTIMALLY mean?

OPTIMALLY adverb
  1. In an optimal manner.

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