Cryptic crossword clue
Impossible if blues fan changes, accepting Queen 12

The most common and most likely answer to this crossword clue is the 12 letter word INSUFFERABLE

I've seen this crossword clue in The Daily Telegraph
I
N
S
U
F
F
E
R
A
B
L
E

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INSUFFERABLE mean?

INSUFFERABLE adjective
  1. Not sufferable; very difficult or impossible to endure.

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