Cryptic crossword clue
Impressionist painter’s room in a mess 12

The most common and most likely answer to this crossword clue is the 12 letter word IMPERSONATOR

I've seen this crossword clue in The Sunday Telegraph
I
M
P
E
R
S
O
N
A
T
O
R


Buddy explains!

The straight part
We know that "Impressionist" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case impressionist = impersonator.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPERSONATOR mean?

IMPERSONATOR noun
  1. One who fraudulently impersonates another person.
  2. An entertainer whose act is based upon performing impressions of others.

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