Cryptic crossword clue
In a maddening way, shrewd Brown standing inside 13

The most common and most likely answer to this crossword clue is the 13 letter word FRUSTRATINGLY

I've seen this crossword clue in The Guardian
F
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Buddy explains!

The straight part
We know that "In a maddening way" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in a maddening way = frustratingly.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FRUSTRATINGLY mean?

FRUSTRATINGLY adverb
  1. In a frustrating manner; in a manner that causes frustration.

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