Cryptic crossword clue
In America, nothing left in little house illegally occupied 6-5

The most common and most likely answer to this crossword clue is the 6 letter word DIDDLY

I've seen this crossword clue in The Times
D
I
D
D
L
Y

Buddy explains!

The straight part
We know that "In America, nothing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in america, nothing = diddly.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DIDDLY mean?

DIDDLY noun
  1. A small amount of no worth.
DIDDLY interjection
  1. A written representation of a trill sound.
DIDDLY noun
  1. (sometimes childish) penis

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