The most common and most likely answer to this crossword clue is the 2 plus 4 letter word AS SUCH
I've seen this crossword clue in Independent
A
S
S
U
C
H
More clues leading to the result AS SUCH
- . In a particular capacity, special force in Germany also provides cover
- Donkey starts to untie cheap harness by itself
- In that capacity, a fascist group beheaded the Miller’s Son
- In and of itself, a swear word repelled Henry
- Bottom hospital in that regard
- A fool often goes topless in the manner described
- In a particular capacity, one stubborn chap’s elevated above Head of House
- A second, so great in itself
- Southern capitals getting covered in dust? Exactly
Buddy explains!
The straight part
We know that "In and of itself" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in and of itself = as such.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.