Cryptic crossword clue
In Ayr aim to make permanent home, having abandoned south 5

The most common and most likely answer to this crossword clue is the 5 letter word ETTLE

E
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E

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The straight part
We know that "In Ayr aim" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in ayr aim = ettle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ETTLE mean?

ETTLE noun
  1. Intention; intent; aim.
ETTLE verb
  1. To aim; purpose; intend; attempt; try.
  2. To expect; reckon; count on.
  3. To take aim.
  4. To make attempt.
  5. To direct one's course.
  6. To aspire; be ambitious.
ETTLE verb
  1. To earn.

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