Cryptic crossword clue
In compliant mode after initial post-menopausal change? Big time! 9

The most common and most likely answer to this crossword clue is the 9 letter word MASSIVELY

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does MASSIVELY mean?

MASSIVELY adverb
  1. In a massive manner, in a way that appears large, heavy or imposing.
  2. Greatly.

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