Cryptic crossword clue
In no case loose the rein 7

The most common and most likely answer to this crossword clue is the 7 letter word NEITHER

I've seen this crossword clue in The Guardian
N
E
I
T
H
E
R


Buddy explains!

The straight part
We know that "In no case" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in no case = neither.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEITHER mean?

NEITHER adverb
  1. Similarly not.
NEITHER pronoun
  1. Not either one of two.
NEITHER conjunction
  1. Not either (used with nor).

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