Cryptic crossword clue
In S America, plain students meet with a refusal! 5

The most common and most likely answer to this crossword clue is the 5 letter word LLANO

I've seen this crossword clue in Financial Times
L
L
A
N
O


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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LLANO mean?

LLANO noun
  1. A plain or steppe in parts of Latin America.

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