Cryptic crossword clue
In shtook, muckiest pup’s head and hands aloft! 5,2,2

The most common and most likely answer to this crossword clue is the 5 plus 2 plus 2 letter word STICK EM UP

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Buddy explains!

The straight part
We know that "hands aloft!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hands aloft! = stick em up.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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