Cryptic crossword clue
In speculative activity, one is right, possibly 10

The most common and most likely answer to this crossword clue is the 10 letter word THEORISING

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Buddy explains!

The straight part
We know that "In speculative activity" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in speculative activity = theorising.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THEORISING mean?

THEORISING verb
  1. To formulate a theory, especially about some specific subject.
  2. To speculate.
THEORISING noun
  1. The formation of theories.

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