The most common and most likely answer to this crossword clue is the 7 letter word HOWEVER
I've seen this crossword clue in The Sunday Telegraph
H
O
W
E
V
E
R
More clues leading to the result HOWEVER
- Call to Bottom: no answer, though
- But we must supplant president’s last love
- Hang about taking in extremely well-made still
- Float carrying you and I, still
- Beyond the low hill it’s always still
- Anyway, bee escapes web to fly outside
- Still hang around drinking wine, disheartened
- Doctor Who always just the same
- Old Chancellor with very regal character at all events
- But I, royally, hang around outside
Buddy explains!
The straight part
We know that "In spite of all that" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in spite of all that = however.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HOWEVER mean?
HOWEVER adverb- Nevertheless; yet, still; in spite of (that).
- (degree) To whatever degree or extent
- (manner) In whatever way or manner.
- An emphatic form of how.
- In any case, at any rate, at all events.
- In whatever way or manner.
- Although, though, but, yet.