Cryptic crossword clue
In spite of that, nearly everything was considered endlessly 8

The most common and most likely answer to this crossword clue is the 8 letter word ALTHOUGH

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "In spite of that" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in spite of that = although.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ALTHOUGH mean?

ALTHOUGH conjunction
  1. Though, even though, in spite of or despite the fact that: introducing a clause that expresses a concession.
  2. But, except.

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