The most common and most likely answer to this crossword clue is the 6 letter word IMBIBE
I
M
B
I
B
E
More clues leading to the result IMBIBE
- Take in confession of AC/DC chap live
- In the course of climb, I bend down
- The setter’s most reliable reference work’s not left down!
- I’m seen with Bible forsaking large drink
- Setter and setter drinking drink and drink
- Taking part in climb, I begin to drink
- Setter’s right out of sweetener for drink
- That’s to go around protective covering on Mark’s neck
- Without apron, spill head of lime drink
- During climb, I begin to drink
Buddy explains!

The straight part
We know that "down" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case down = imbibe.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IMBIBE mean?
IMBIBE verb- To drink (used frequently of alcoholic beverages).
- To take in; absorb.