Cryptic crossword clue
In the end, John associating with Yoko is something unacceptable 2-2

The most common and most likely answer to this crossword clue is the 5 letter word NO-NO

I've seen this crossword clue in Financial Times
N
O
-
N
O

Buddy explains!

The straight part
We know that "something unacceptable" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case something unacceptable = no-no.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NO-NO mean?

NO-NO noun
  1. Something that is forbidden, prohibited, discouraged or taboo.
  2. A no-hitter; a game in which no batter on one of the teams got a hit.

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