The most common and most likely answer to this crossword clue is the 6 letter word UNWELL
I've seen this crossword clue in The Guardian
U
N
W
E
L
L
More clues leading to the result UNWELL
- You must get bit of nitro and spring crook
- Funny upper-class name? Considerably
- In the long run, we’ll get sick
- Multinational organisation we will cut is in poor shape
- Parisian article effectively in poor condition
- To such a person French spa might be the answer
- Ailing, spring after peacekeepers
- A European supplier of oil needing treatment
Buddy explains!

The straight part
We know that "sick" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sick = unwell.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNWELL mean?
UNWELL adjective- Not in good health; not feeling well; somewhat ill
- Specifically, ill from menstruation; affected with, or having, catamenial; menstruant.