The most common and most likely answer to this crossword clue is the 9 letter word NEUTRINOS
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More clues leading to the result NEUTRINOS
Buddy explains!

The straight part
We know that "they are so small" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they are so small = neutrinos.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does NEUTRINOS mean?
NEUTRINOS noun- An elementary particle that is classified as a lepton, and has an extremely small but nonzero mass and no electric charge. It interacts with the surroundings only via the weak force or gravitation, making it very difficult to detect.