Cryptic crossword clue
In your mouth, it’s tender fruitless sweet spot 7

The most common and most likely answer to this crossword clue is the 7 letter word GUMBOIL

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "In your mouth, it’s tender" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in your mouth, it’s tender = gumboil.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GUMBOIL mean?

GUMBOIL noun
  1. A small suppurating inflamed spot on the gum.

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