Cryptic crossword clue
Inanity of southern disease overwhelming setter 9

The most common and most likely answer to this crossword clue is the 9 letter word SILLINESS

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Buddy explains!

The straight part
We know that "Inanity" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case inanity = silliness.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SILLINESS mean?

SILLINESS noun
  1. That which is perceived as silly or frivolous.
  2. An act that is silly; a result of being silly.

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