Cryptic crossword clue
Indifference to pain is most unusual dressing raw cut 8

The most common and most likely answer to this crossword clue is the 8 letter word STOICISM

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Buddy explains!

The straight part
We know that "Indifference to pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case indifference to pain = stoicism.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STOICISM mean?

STOICISM noun
  1. A school of philosophy popularized during the Roman Empire that emphasized reason as a means of understanding the natural state of things, or logos, and as a means of freeing oneself from emotional distress.
  2. A real or pretended indifference to pleasure or pain; insensibility; impassiveness.

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