Cryptic crossword clue
Infants pictured playing with umpteen toys, though irascible initially 5

The most common and most likely answer to this crossword clue is the 5 letter word PUTTI

I've seen this crossword clue in The Times
P
U
T
T
I

Buddy explains!

The straight part
We know that "Infants pictured" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case infants pictured = putti.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PUTTI mean?

PUTTI noun
  1. A representation, especially in Renaissance or Baroque art, of a small, naked, often winged (usually male) child; a cherub.

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