Cryptic crossword clue
Inflexible doctor with refusal left one suffering itch 10

The most common and most likely answer to this crossword clue is the 10 letter word MONOLITHIC

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Buddy explains!

The straight part
We know that "Inflexible" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case inflexible = monolithic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MONOLITHIC mean?

MONOLITHIC adjective
  1. Of or resembling a monolith.
  2. Having a massive, unchanging structure that does not permit individual variation.
  3. (said of an operating system's kernel) consisting of a single program using a single memory-addressing space

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