The most common and most likely answer to this crossword clue is the 5 letter word GRIME
I've seen this crossword clue in The Times
G
R
I
M
E
More clues leading to the result GRIME
- Ingrained dirt, dreadful by end of aisle
- Ghastly game's ending in mire
- Dirt, unpleasant, at bottom of scuttle
- For example, going back round edge reveals dirt
- Spain forbidding earlier form of dance music
- Repellent drug, an ingrained phenomenon
- Dirt, for example, seen back round edge
- Muck is dreadful, coming to middle of field
- Good frost creates filth
- Smut produces scowl, putting Bill off
Buddy explains!

The straight part
We know that "Ingrained dirt" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ingrained dirt = grime.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GRIME mean?
GRIME noun- Dirt, grease, soot, etc. that is ingrained and difficult to remove.
- A genre of urban music that emerged in London, England, in the early 2000s, primarily a development of UK garage, dancehall, and hip hop.
- To begrime; to cake with dirt.