The most common and most likely answer to this crossword clue is the 8 letter word MALAISES
I've seen this crossword clue in Independent
M
A
L
A
I
S
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S
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MALAISES mean?
MALAISES noun- A feeling of general bodily discomfort, fatigue or unpleasantness, often at the onset of illness.
- An ambiguous feeling of mental or moral depression.
- Ill will or hurtful feelings for others or someone.