Cryptic crossword clue
Initially speak about my poor friend with feeling 15

The most common and most likely answer to this crossword clue is the 15 letter word SYMPATHETICALLY

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Buddy explains!

The straight part
We know that "with feeling" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with feeling = sympathetically.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SYMPATHETICALLY mean?

SYMPATHETICALLY adverb
  1. Owing to or showing evidence of "sympathy", or affinity; happening through or demonstrating correspondences, whether occult or physiological.
  2. In a manner which demonstrates a sharing in the feelings of others; compassionately.

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