Cryptic crossword clue
Injuring knee lower, dagger’s first to go in — is that sharp practice? 10

The most common and most likely answer to this crossword clue is the 10 letter word NEEDLEWORK

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "is that sharp practice?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case is that sharp practice? = needlework.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEEDLEWORK mean?

NEEDLEWORK noun
  1. The art or process of working with a needle especially in embroidery or needlepoint.
  2. The product of such art or process.
  3. The occupation or employment of a person skilled in embroidery, needlepoint, etc.

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