The most common and most likely answer to this crossword clue is the 4 plus 3 letter word DEAD SEA
I've seen this crossword clue in The Times
D
E
A
D
S
E
A
More clues leading to the result DEAD SEA
- Inland lake completely enclosed at first in S Africa?
- Very bottom drops back in lowest lake
- Old man with sweetheart in spot — reportedly a very low point
- Bill’s in river, a very low stretch of water
- These days needing backing to keep daughter in comfort in depressed area
- What’s ever-so briny?
- Directly observe in sound a body of water
- Desalinated production abandoning troubled int’l waters
- There’s no catch in it
- Diehards seen at every other Middle Eastern tourist spot
Buddy explains!

The straight part
We know that "Inland lake" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case inland lake = dead sea.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.