Cryptic crossword clue
Innkeeper is throttled by guest on vacation — most creepy 10

The most common and most likely answer to this crossword clue is the 10 letter word GHOSTLIEST

G
H
O
S
T
L
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E
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T

Buddy explains!

The straight part
We know that "most creep" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most creep = ghostliest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GHOSTLIEST mean?

GHOSTLIEST adjective
  1. Of or pertaining to ghosts or spirits.
  2. Spooky; frightening.
  3. Relating to the soul; not carnal or secular; spiritual.

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