The most common and most likely answer to this crossword clue is the 11 letter word SPECULATION
I've seen this crossword clue in The Daily Telegraph
S
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More clues leading to the result SPECULATION
Buddy explains!
The straight part
We know that "guessing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guessing = speculation.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SPECULATION mean?
SPECULATION noun- The process of thinking or meditating on a subject.
- The act or process of reasoning a priori from premises given or assumed.
- A conclusion to which the mind comes by speculating; mere theory; notion; conjecture.
- An investment involving higher-than-normal risk in order to obtain a higher-than-normal return.
- The act or practice of buying land, goods, shares, etc., in expectation of selling at a higher price, or of selling with the expectation of repurchasing at a lower price; a trading on anticipated fluctuations in price, as distinguished from trading in which the profit expected is the difference between the retail and wholesale prices, or the difference of price in different markets.
- Examination by the eye; view.
- Power of sight.
- A card game in which the players buy from one another trumps or whole hands, upon a chance of getting the highest trump dealt, which entitles the holder to the pool of stakes.
- The process of anticipating which branch of code will be chosen and executing it in advance.