Cryptic crossword clue
Insignificance of man with no picture being shot 12

The most common and most likely answer to this crossword clue is the 12 letter word UNIMPORTANCE

I've seen this crossword clue in The Daily Telegraph
U
N
I
M
P
O
R
T
A
N
C
E

Buddy explains!

The straight part
We know that "Insignificance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case insignificance = unimportance.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNIMPORTANCE mean?

UNIMPORTANCE noun
  1. Lack of importance.

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