Cryptic crossword clue
Insignificant alien overwhelmed by depression 5

The most common and most likely answer to this crossword clue is the 5 letter word PETIT

P
E
T
I
T

Buddy explains!

The straight part
We know that "Insignificant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case insignificant = petit.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PETIT mean?

PETIT noun
  1. (usually in the plural) A little schoolboy.
  2. A kind of pigeon.
PETIT adjective
  1. (of size) Petite: small, little.
  2. Petty, in its various senses:
PETIT noun
  1. The size of type between minion and bourgeois, standardized as 8-point.

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