Cryptic crossword clue
Instigates Times leader being changed 7

The most common and most likely answer to this crossword clue is the 7 letter word FOMENTS

I've seen this crossword clue in The Daily Telegraph
F
O
M
E
N
T
S

Buddy explains!

The straight part
We know that "Instigates" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instigates = foments.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FOMENTS mean?

FOMENTS verb
  1. To incite or cause troublesome acts; to encourage; to instigate.
  2. To apply a poultice to; to bathe with a cloth or sponge.

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