The most common and most likely answer to this crossword clue is the 10 letter word SQUEEZEBOX
I've seen this crossword clue in The Guardian
S
Q
U
E
E
Z
E
B
O
X
Buddy explains!
The straight part
We know that "Instrument played" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instrument played = squeezebox.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SQUEEZEBOX mean?
SQUEEZEBOX noun- A small, portable, keyed wind instrument, whose tones are generated by play of the wind from a squeezed bellows upon free metallic reeds.
- A vertical list of items that can be individually expanded and collapsed to reveal their contents.
- A therapeutic device designed to apply pressure to the body of a hypersensitive person (usually someone on the autism spectrum) in order to calm them by providing grounding sensory stimulation.
- A box with an adjustable opening used by cavers to practise crawling through tight spaces.
- A container that fits tightly around an animal to immobilize it for medical treatment, transportation, etc.