Cryptic crossword clue
Instrument put Il Duceinitially right out Mussolini

The most common and most likely answer to this crossword clue is the 8 letter word DULCIMER

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "Instrument" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instrument = dulcimer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DULCIMER mean?

DULCIMER noun
  1. A stringed instrument, with strings stretched across a sounding board, usually trapezoidal. It is played on the lap or horizontally on a table. Some have their own legs. These musical instruments are played by plucking on the strings (traditionally with a quill) or by tapping on them (in the case of the hammer dulcimers).

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