Cryptic crossword clue
Instrumentalist‘s passionate desire to hold note 6

The most common and most likely answer to this crossword clue is the 6 letter word LUTIST

L
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T

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The straight part
We know that "Instrumentalist" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instrumentalist = lutist.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LUTIST mean?

LUTIST noun
  1. One who plays the lute.

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