The most common and most likely answer to this crossword clue is the 6 letter word KIBITZ
K
I
B
I
T
Z
Buddy explains!

The straight part
We know that "Interfere" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case interfere = kibitz.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does KIBITZ mean?
KIBITZ verb- To make small talk or idle chatter.
- To give unsolicited or unwanted advice or make unhelpful or idle comments, especially to someone playing a game.
- To watch a card or board game.