The most common and most likely answer to this crossword clue is the 6 letter word NOBBLE
I've seen this crossword clue in The Sunday Telegraph
N
O
B
B
L
E
More clues leading to the result NOBBLE
- Steal gold coin bishop preserved
- Aristocrat pens book revealing bribe
- Grab someone of distinction, competent but no leader
- Get at person entitled to entertain bishop
- Interfere with person who’s entitled to hold key
- Leading batsman’s in good nick
- Arrest peer, baron put inside
- One aristocrat frames another to incapacitate a horse
Buddy explains!

The straight part
We know that "Interfere with" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case interfere with = nobble.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does NOBBLE mean?
NOBBLE verb- To injure or obstruct intentionally.
- To gain influence by corrupt means or intimidation.
- To steal.
- To tamper (typically with a racehorse) in order to prevent from winning a race