Cryptic crossword clue
Interrogates new doctor, initially — is medicine holding up one’s illness? 13

The most common and most likely answer to this crossword clue is the 13 letter word INDISPOSITION

I've seen this crossword clue in The Sunday Telegraph
I
N
D
I
S
P
O
S
I
T
I
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N

Buddy explains!

The straight part
We know that "illness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case illness = indisposition.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INDISPOSITION mean?

INDISPOSITION noun
  1. A mild illness, the state of being indisposed.
  2. A state of not being disposed to do something; disinclination; unwillingness.
  3. A bad mood or disposition.

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