Cryptic crossword clue
Intolerant sort swallows pill to become most spirited 7

The most common and most likely answer to this crossword clue is the 7 letter word RACIEST

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "most spirited" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most spirited = raciest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RACIEST mean?

RACIEST adjective
  1. Mildly risqué.
  2. Having a strong flavor indicating origin; of distinct characteristic taste; tasting of the soil.
  3. (by extension) Exciting to the mind by a strong or distinctive character of thought or language; peculiar and piquant; fresh and lively.
  4. Involving a data race or a race condition.

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