The most common and most likely answer to this crossword clue is the 4 letter word SOMA
I've seen this crossword clue in Independent
S
O
M
A
More clues leading to the result SOMA
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The straight part
We know that "Intoxicating juice/perfect drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case intoxicating juice/perfect drug = soma.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SOMA mean?
SOMA noun- The whole axial portion of an animal, including the head, neck, trunk, and tail.
- The corporeal body, as distinguished from the psyche or soul and the pneuma or spirit.
- The bulbous part of a neuron, containing the cell nucleus.
- (hinduism) A ritual drink in ancient Vedic and continuing Hindu culture, obtained by pressing the Soma plant.
- (by extension) Any kind of intoxicating drug.