Cryptic crossword clue
Intuitive knowledge upset number one son 6

The most common and most likely answer to this crossword clue is the 6 letter word GNOSIS

I've seen this crossword clue in The Guardian
G
N
O
S
I
S


Buddy explains!

The straight part
We know that "Intuitive knowledge" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case intuitive knowledge = gnosis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GNOSIS mean?

GNOSIS noun
  1. (gnosticism) an immanent form of knowledge or transcendent insight, such as sought by the Gnostics
  2. Act or process of knowing
  3. An altered state of awareness in which the will is magically effective

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