The most common and most likely answer to this crossword clue is the 15 letter word VALETUDINARIANS
I've seen this crossword clue in Financial Times
V
A
L
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D
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More clues leading to the result VALETUDINARIANS
Buddy explains!

The straight part
We know that "hypochondriacs" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hypochondriacs = valetudinarians.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does VALETUDINARIANS mean?
VALETUDINARIANS noun- A person in poor health or sickly, especially one who is constantly obsessed with their state of health