Cryptic crossword clue
Invalidates foremost luxury liner in America that has a prominent Nazi aboard 5

The most common and most likely answer to this crossword clue is the 5 letter word NULLS

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The straight part
We know that "Invalidates" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case invalidates = nulls.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NULLS mean?

NULLS noun
  1. A non-existent or empty value or set of values.
  2. Zero quantity of expressions; nothing.
  3. Something that has no force or meaning.
  4. The ASCII or Unicode character (␀), represented by a zero value, that indicates no character and is sometimes used as a string terminator.
  5. The attribute of an entity that has no valid value.
  6. One of the beads in nulled work.
  7. Null hypothesis.
NULLS verb
  1. To nullify; to annul.
  2. To form nulls, or into nulls, as in a lathe.
  3. To crack; to remove restrictions or limitations in (software).

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