Cryptic crossword clue
Involving vital element, poisonous with lead removed 4

The most common and most likely answer to this crossword clue is the 4 letter word OXIC

O
X
I
C

Buddy explains!

The straight part
We know that "Involving vital element" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case involving vital element = oxic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OXIC mean?

OXIC adjective
  1. Sharp; pointy.
OXIC adjective
  1. Containing oxygen.

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