Cryptic crossword clue
Irish girl experiencing pins and needles in irksome way 12

The most common and most likely answer to this crossword clue is the 12 letter word IRRITATINGLY

I've seen this crossword clue in Financial Times
I
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Buddy explains!

The straight part
We know that "in irksome way" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in irksome way = irritatingly.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IRRITATINGLY mean?

IRRITATINGLY adverb
  1. In an irritating way; in a manner causing irritation, or that irritates.

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