The most common and most likely answer to this crossword clue is the 5 letter word TECHY
I've seen this crossword clue in The Times
T
E
C
H
Y
More clues leading to the result TECHY
Buddy explains!

The straight part
We know that "Irritable/computer whizz?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case irritable/computer whizz? = techy.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TECHY mean?
TECHY adjective- Technical
- Easily annoyed or irritated; peevish, testy or irascible.